Illustrative examples of the involvement of disordered proteins in disease include the Cip/Kip cell cycle inhibitors, breast cancer type 1 susceptibility protein, and securin in the case of cancer, amyloid β, tau, α-synuclein, and huntingtin in the case of neurodegenerative disorders, and amylin (IAPP) in the case of type II diabetes [13]. The gene discussed is IAPP; the disease is type 2 diabetes mellitus.