In addition, transcription factors that play important role in EMT, such as twist family BHLH transcription factor-1 (TWIST-1), zinc finger E-box binding homeobox-1 (ZEB-1)/ZEB-2, and snail family transcriptional repressor-1 (SNAIL-1)/SNAIL-2, were found to be altered in GBM [38, 39] as the proneural cells undergo transformation to mesenchymal subtype. This evidence concerns the gene ZEB1 and glioblastoma.