INS and type 1 diabetes mellitus: In the WESDR (Wisconsin Epidemiologic Study of Diabetic Retinopathy), the 10-year incidence of DME was 20.1% among patients with type 1 diabetes, 13.9% among type 2 diabetics using insulin, and 25.4% among type 2 diabetes patients not using insulin.1 Without timely and appropriate treatment, DME leads to permanent vision loss.