We also determined whether antigen presentation and other immune-related genes (B2M, CD3E, CD4, CD8A, GZMA, GZMB, HLA-A, HLA-B, HLA-C, IFNG, LCK, PRF1, LMP7, LMP2, TAP1, and TAP2) are associated with PRAME and found that expression of multiple genes involved in antigen presentation (HLA-B, HLA-C, B2M, LMP2, LMP7, TAP2) negatively correlate with PRAME expression in dedifferentiated liposarcoma and leiomyosarcoma (Fig. 4d). The gene discussed is PSMB8; the disease is liposarcoma.