In this study, we demonstrated that expression of renal α-SMA, TGF-β, and FN in rats of the FSGS model group, losartan group, Shenshu moxibustion group, and Geshu moxibustion group was higher than in the sham-operation group, suggesting that renal interstitial fibrosis occurs in rats after FSGS modeling. Here, ACTA1 is linked to focal segmental glomerulosclerosis.