Consequently, it was reported that IL-4/STAT-6 pathway is involved in asthma pathogenesis because STAT-6 activation lead to the differentiation of naïve T-cells into Th2 effector cells, and it regulates the production of Th2 chemokine induced by IL-4 and IL-13 [38, 39]. The gene discussed is IL4; the disease is asthma.