HMGB1 and asthma: The expression of HMGB1 and TLR4 mRNAs in 1,25-(OH)2D3 low and middle dose groups was considerably lower than the asthma group and higher than the control one; the high dose group had an augmented expression of HMGB1 and TLR4 mRNAs compared to the asthmatic group [22].