DISC1 and schizophrenia: The DISC1 Regulome gene set was assembled from genes that show both i) altered expression in response to genetic variation in DISC1 or its interactors, or are themselves protein interactors of the core complex, and ii) evidence of association with psychiatric illness from candidate gene studies, or some of the earliest genome-wide association studies.1, 56, 57 We note that in this study, we found nominal association of rare Regulome variants with both increased schizophrenia risk and lower adult cognitive ability, particularly in older age.