This mirrors the observation of association with common variants from the DISC1 Regulome in GWAS studies.8, 9, 58, 59 Overall, the patterns of associations seen across diagnostic and cognitive traits in the DISC1 Interactome and Regulome are consistent with the hypothesis that genetic disruption of DISC1 or its direct interactors has a proximal effect on cognitive ability and a distal effect, through regulation of gene expression, on schizophrenia risk in later life. Here, DISC1 is linked to schizophrenia.