INS and type 2 diabetes mellitus: Results remained also unchanged after excluding early insulin users (and matched non-users) who initiated therapy within 6 months after T2DM diagnosis [adjusted SHR 2.00 (1.45 to 2.77)]; similarly, reclassifying insulin use in the first two months of treatment as non-user time obtained similar findings to our main analysis [adj SHR 1.28 (0.96 to 1.71)].