Recently, X Tang et al. reported that cystine deprivation triggered necrosis in triple-negative breast cancer (TNBC) cells34, and Feng Wang et al. found that ADR increased the expression of SLC7A11 in TNBC, while the inhibition of the SLC7A11 antiporter system sensitized TNBC cells to ADR35. The gene discussed is SLC7A11; the disease is triple-negative breast carcinoma.