To determine the performance of LIPSTICKS for detecting autoantibodies for SS diagnosis, a cohort of serum samples from healthy controls (n = 20) and SS patients (n = 28) were evaluated by LIPSTICKS using Renilla luciferase-Ro60, Renilla luciferase-Ro52 and Renilla luciferase-La and the results were compared with clinical ELISA data. This evidence concerns the gene SSB and synovial sarcoma.