We show that when Zn2+ levels were elevated to concentrations reported to occur in chronic heart failure (>1 nm) where RyR2 and MG23 gate together, construction of an all-points amplitude histogram revealed that channel openings resided in two open states, one with a mean current amplitude consistent with the full open state of RyR2 and another with a mean current amplitude that is consistent with the unitary current amplitude of the reported RyR2 sub-conductance state. The gene discussed is TMEM109; the disease is congestive heart failure.