Statistical analysis revealed that S100A7 status was positively correlated with stage (P = 0.016), Ki-67 labeling index (LI) (P < 0.0001), histological grade (P = 0.027), and lymph node metastasis (P = 0.038) in the patients examined, and that it was negatively associated with ER (P = 0.001) and PR (P = 0.001) status (Table 1). The gene discussed is ESR1; the disease is metastatic malignant neoplasm in the lymph nodes.