Since AMPAR signaling to KRAS and MAPK pathways, promoted migration and invasion of cells [51], and GRIA3 acted as an important mediator of survival, proliferation, and migration of tumor cell, which, in pancreatic cancer, are regulated by CUX1 downstream of PI3K/AKT [52], we investigated the MAPK/ERK and PI3K/AKT signaling pathways in the migration and invasion of NSCLC cells. Here, CUX1 is linked to familial pancreatic carcinoma.