Recent studies that outlined the genomic and molecular characterization of esophageal carcinoma in the Asian population suggested the dysregulation of the receptor tyrosine kinase (RTK)-MAPK-PI3K, NOTCH, Hippo, cell cycle, and epigenetic pathways as the primary molecular mechanism of ESCC [44, 47]. Here, NTRK1 is linked to esophageal squamous cell carcinoma.