The TL1A/death receptor 3 (DR3/TNFRSF25) axis is a novel immune pathway that participates in the pathogenesis of a variety of autoimmune rheumatic diseases [10], thus molecules involved in regulating TL1A/DR3 axis are regarded as promising therapeutic targets for various inflammatory and autoimmune diseases [12]. This evidence concerns the gene TNFRSF25 and autoimmune disease.