It is interesting to note that treatment of renal cell carcinoma cell lines (ACHN and 769-P) with both the PI3K-inhibitor LY294002 and the AKT-inhibitor IV results in a strongly reduced DcR3 expression on both protein and mRNA levels, indicating DcR3 is upregulated by PI3K/AKT-dependent pathway [61]. The gene discussed is AKT1; the disease is renal cell carcinoma.