APC and colorectal carcinoma: Although the APCMin/+ mice has frequently been used to investigate the mechanisms of intestinal tumorigenesis, APC∆14/+ mice (which harbour a heterozygous mutation resulting in deletion of exon 14 of the APC tumour suppressor gene [13]) are a better model of human CRC as in addition to the small intestinal tumours observed in APCMin/+ mice, APC∆14/+ mice also develop tumours in the distal colon and rectum.