The result showed that non-HBV controls and CHB patients had 2.67-fold and 2.08-fold higher ATF6 mRNA levels than HCC patients (P = 5.38E-79), and 2.78-fold and 2.16-fold higher ASNS mRNA levels than HCC patients (P = 9.05E-82). This evidence concerns the gene ATF6 and hepatocellular carcinoma.