When inflammation occurs, tumor cells, macrophages, and other tumor infiltrating immune cells possess high reactive oxygen species (ROS), and secrete chemokines and cytokines such as IL-6, tumor necrosis factor (TNF)-α, IL-1β, IL-10, and transforming growth factor (TGF)-β to tumor microenvironment [80]. This evidence concerns the gene TGFB1 and neoplasm.