IFNG and autosomal dominant cutis laxa: Additionally, patients with ADCL have significantly fewer circulating and lesional innate natural killer (NK) cells than LCL patients, and the NK cells present secrete less IFNγ and TNF than LCL NK cells following stimulation with Leishmania lipophosphoglycan, a parasite surface glycolipid that can ligate Toll-like receptor 2 [117].