CSF1R and Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia: Interestingly, the CSF-1R mutations all occur in the kinase domain and lead to reduced expression and phosphorylation of the receptor, indicating that CSF-1R haploinsufficiency is sufficient to cause HDLS, which is also known as adult-onset leukodystrophy, with axonal spheroids and pigmented glia (ALSP) [30,31].