With the identification of two core CSF-1R-triggered motility pathways involving PI3K p110δ and Hck that are selectively expressed in hematopoietic cells and abundantly expressed in macrophages, we can now specifically target migratory macrophages to prevent their promotion of tumor invasion without depleting tumors of more stationary TAM populations that may be providing anti-tumoral functions. Here, HCK is linked to neoplasm.