Speliotes et al. reported that, along with PNPLA3, variants in Protein Phosphatase 1 Regulatory Subunit 3B (PPP1R3B), Glucokinase Regulatory Protein (GCKR), Neurocan (NCAN) and Lysophospholipase Like 1 (LYPLAL1) genes were also associated with NAFLD [10]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.