Two SNPs (rs2854116 and rs2854117) in high linkage disequilibrium within the APOC3 gene have been associated with hypertriglyceridemia and NAFLD [63,64] The first variant encodes for a substitution of threonine to cysteine at 455 position, and the second drives a cysteine to threonine change at 482 residue. Here, APOC3 is linked to metabolic dysfunction-associated steatotic liver disease.