In a large obese pediatric population, children with at least one minor allele (T) more frequently showed NAFLD, higher Alanine Transaminase (ALT) and lower non-High Density Lipoprotein (non-HDL) cholesterol serum levels, even after adjustment for anthropometrical parameters and the PNPLA3 I148M genotype [37]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.