CCN2 and keloid: Normal human dermal fibroblasts (NHDF, Adult) and keloid fibroblasts (KEL FIB) were tested with different concentrations of genistein; the keloid fibroblast culture revealed an increase of CTGF mRNA and an increase of CTGF protein expression compared to normal fibroblast, confirming the contribution of CTGF in keloid fibroblast pathology [17].