AGER and metabolic dysfunction-associated steatotic liver disease: Considering that AGE and RAGE are pivotal participants in vasculature injury in several diseases, including diabetes and Alzheimer [15,22], and that Kupffer cells and liver sinusoidal endothelial cells (LSEC) are the major cellular sites of AGE uptake and clearance [23,24,25], AGE accumulation in the liver could participate in hepatic microvascular damage, further exacerbating liver dysfunction and contributing to NAFLD progression.