TNFSF13B and systemic lupus erythematosus: Although GCs are important for the production of IgG autoantibodies, several lupus-prone mouse models including RF IgG2a, MRL.Faslpr (anti-DNA) and BAFF-Tg have a marked predominance of short-lived, splenic plasmablasts [46–48], which raises the question of how much of the breach of tolerance is mediated through GC responses as compared to extrafollicular activation.