IL13 and allergic asthma: As stated above, the literature suggests that the immune mechanism underlying the effects of soybean aeroallergens on asthma onset and exacerbation and even on asthma outbreaks is an allergic asthma response based on allergen-driven Th2 inflammation, in which interleukins IL-4, IL-5, and IL-13 are the main mediators [38].