CASP12 and Familial prostate cancer: Curcumin PC3 treated cells induced a significantly higher expression of caspase 12 when compared to DMSO, with a peak percent in the range of 75% vs. 25% in DMSO (Fig 2F, p value ≤ 0.0017), suggesting that curcumin triggers a chronic ER stress induced cell death in prostate cancer cells.