When looking at lung histology, no difference was observed in the perivascular, peribronchial and parenchymal inflammation between both strains following SR exposure (Fig 2A and 2B), suggesting that in our model, only the severity of the airway inflammation / alveolitis is regulated by CD103 expression, which is the major hallmark of this specific pathology. This evidence concerns the gene ITGAE and hypersensitivity pneumonitis.