As recently demonstrated in a model of hyperlipidemia, the bi-functional NTM cSN50.1 used herein also modulates nuclear transport of SREBPs and carbohydrate-responsive element binding protein (ChREPB), transcription factors responsible for lipid and carbohydrate homeostasis, respectively, in addition to reducing nuclear transport of SRTFs [19]. Here, MLXIPL is linked to hyperlipidemia.