PRKCI and breast cancer: Studies have shown that the 3 genes in LMCT-7 are all associated with tumor metastasis: PRKCI is over-expressed in lymph node metastasis of esophageal cancer and can be used as a biomarker of metastasis[34], JAG1 can promote metastasis of breast cancer and lung cancer[35, 36], and MPP3 can promote the migration and invasiveness of liver cancer[37].