(i.e., JAG1, KNG1, MYO5C, MYCN and ACTN2) Among 276 CRC samples in TCGA database, we found the CRC patients with alteration in KNG1 (p = 0.0215) or MYO5C (p = 0.0312) had lower survival rates than the CRC patients with normal KNG1 or MYO5C expression. The gene discussed is KNG1; the disease is colorectal carcinoma.