Therefore, our results show a consistent differential expression of HMGB1, MICB, PSMB8, PSMB2, PSME2, HDAC1, HDAC2 and DNMT3B when compared to other sepsis cases, irrespective of comorbidities (risk factors), duration of fever/clinical symptoms and antibiotic treatment, primarily due to melioidosis infection. The gene discussed is HDAC1; the disease is Sepsis.