It has been shown that the concurrent activation of NF-κB and Wnt signaling pathways promotes a stem cell-like state.30 Accordingly, it is also conceivable that the Trp53 mutation induces stemness or an undifferentiated status of tumor cells through the simultaneous activation of inflammatory pathways and Wnt signaling (Supplementary Figure 6). This evidence concerns the gene NFKB1 and neoplasm.