The data showed that the promoter regions of Hoxa9, Hoxa10, Gata2 and Lef1 genes were substantially more sensitive to the nuclease treatment in ApcΔ716Trp53R270H/R270H tumor cells than in ApcΔ716Trp53+/+ and ApcΔ716Trp53flox/flox (Supplementary Figure 5c). Here, GATA2 is linked to neoplasm.