TNF and malignant colon neoplasm: We have previously demonstrated that inflammatory responses have a role in the malignant progression of intestinal tumors.36 It has been reported that mutant p53 prolongs TNF-α-induced NF-κB activation, which results in highly prone to inflammation-associated colon cancer,16 and that mutant p53 facilitates TNF-α signaling.37 These results, taken together, suggest that mutant p53 has a role in malignant progression through the induction of the inflammatory pathway.