As the nuclear accumulation of p53 is restricted to the submucosal invasive area of ApcΔ716Trp53+/R270H tumors (Figure 2e), we separately collected tumor cells from the invasive and non-invasive areas of ApcΔ716Trp53+/R270H mouse tumors by laser microdissection (Figure 6b), and analyzed the expression of the eight validated genes by real-time RT-PCR (Figure 6c). Here, TP53 is linked to neoplasm.