A striking nuclear accumulation of p53 was observed in the ApcΔ716Trp53R270H/R270H mouse tumors like human CRC with TP53 mutations, whereas p53 was not detected in the ApcΔ716Trp53+/+ and ApcΔ716Trp53+/flox mouse tumors (Figure 2a and Supplementary Figure 2). The gene discussed is TP53; the disease is colorectal carcinoma.