TLR2 and intestinal neoplasm: Importantly, it has been shown that inflammatory and innate immune pathways through NF-κB and TLR2 together with Wnt/β-catenin signaling are important for the acquisition of stem cell properties.30, 38 Accordingly, the present results suggest that mutant p53R270H can induce stem cell properties in intestinal tumor cells through the activation of both NF-κB pathway and Wnt signaling (Figure 7b and Supplementary Figure 6).