Heterozygous disruption of BECN1 leads to spontaneous tumor formation in mice, indicating BECN1 is a halpoinsufficient tumor suppressor,10, 11, 12 mice lacking ATG5, ATG7 or AMBRA1 show similar effect.13, 14, 15 However, autophagy is also involved in oncogenic process in some circumstances. This evidence concerns the gene AMBRA1 and neoplasm.