RB1CC1 and neoplasm: Dysfunction in autophagy pathway suppresses tumor proliferation, dissemination and metastasis.15 Inhibition of autophagy increases sensitivity of tumor cells to chemotherapeutic agents as well as radiation therapy.16, 17, 18 Deletion of FIP200, a component of the ULK1–ATG13–FIP200 complex that is required for autophagosome formation, suppresses tumor initiation and progression.