Taking into account that we did not observe a role for DOT1L as a key regulator of Wnt signalling in primary osteoblasts, novel insights into the role of DOT1L in development and growth may result from experiments with other Cre-drivers such as Prx1. Obviously, specific attention should be given to growth retardation in children affected by leukaemia that are being treated with DOT1L inhibitors. This evidence concerns the gene DOT1L and leukemia.