ERBB2 and neoplasm: The cooperative membrane targeting nanosystem exhibited superior accumulation (greater than fivefold) and more uniform distribution of fluorophore-SA in both peripheral and interior regions compared with injection with fluorophore-SA alone (Fig. 5b), which was also hardly observed with conventional tumour targeting systems, Herceptin (trastuzumab, HER2-targeted antibody)32 and cRGD-SA (αvβ3 intergin-targeting peptide-coated protein)33 (Fig. 5c).