These older egg‐positive children show a schistosome‐specific antibody profile, which indicates a history of previous infection and also associated with the development of protective immunity, beginning to reduce re‐infection levels.83, 84, 85 This finding may indicate that ILC2s play a more pronounced role in the initiation of early immune response at a stage when effective TH2 responses are triggered and a full CD4+ T‐cell‐mediated TH2 response has not yet developed. Here, CD4 is linked to infection.