INS and pancreatic insulinoma: Kang et al. showed that GLP-1 receptor mRNA expression and GLP-1-stimulated insulin secretion were reduced in palmitate-treated rodent insulinoma cell lines and mouse islets [22], and GLP-1 receptor mRNA expression was restored in isolated islet in db/db mice treated with bezafibrate for 2 weeks compared to untreated db/db mice [23].