Xi et al. stated that TIPE2 mRNA expression was substantially diminished in PBMCs from individuals with chronic hepatitis B in contrast to healthy people, and TIPE2 expression was negatively correlated with blood levels of ALT, AST, and total bilirubin (Tbil) and with HBV load in these patients [18]. This evidence concerns the gene TIPE2 and chronic hepatitis B virus infection.