TNF and infection: Under high glucose conditions (50 mmol/L), siTIPE2 infection exacerbated the increased TNF-α and IL-6 concentrations in differentiated THP-1 cells (Figures 4(a) and 4(c)), and Ad-TIPE2 infection reversed the increased TNF-α concentration (Figure 4(b)), while Ad-TIPE2 infection had no obvious effect on the increased IL-6 release (Figure 4(d)).