High level of PD-L1 expression has been observed in some types of lymphomas including a subset of aggressive B cell lymphomas and EBV-associated malignancies such as classical Hodgkin lymphoma (CHL) (Berghoff et al., 2014; Chen et al., 2013; Kwon et al., 2016). Here, CD274 is linked to B-cell non-Hodgkin lymphoma.