FSHR and osteoporosis: In addition to FSH receptors in gonads, low levels of FSH receptors were found in cultured osteoclasts and these receptors have been proposed to promote osteoporosis in postmenopausal women.9 However, these findings were challenged due to an inability to confirm the low expression of FSH receptors in osteoclasts10,11 and difficulties occurred in performing in vitro FSH binding of the rigid bone structures.