Recent studies on colon cancer show that NOX1 activity and ROS generation are modulated through a cascade of interactions between growth receptor-bound protein 2 (an adaptor involved in signal transduction), Cbl E3 ligase (an ubiquitin-protein ligase), NOXA1 (an activator of the NOX complex), epidermal growth factor, and NOXO1 (an organizer of the NOX complex). The gene discussed is NOX1; the disease is colonic neoplasm.