NOX2 has been suggested as a potential target in the development of a therapy against chronic myeloid leukemia (CML) and glioblastoma, as the resistance of CML stem cells and patient-derived glioblastoma stem cells to tyrosine kinase inhibitors seem to be mediated through the NOX2/Egr1/Fyn axis [143]. The gene discussed is FYN; the disease is glioblastoma.