In colon cancer cells, this molecular switch from NOX1 to NOX2, together with NOX2-derived ROS, increases MMP-7 expression by the deactivation of AMPK, and the TPA-induced phenotype can be reverted by NOX2 but not NOX1-targeting siRNA, suggesting that NOX2 activity induces an invasive phenotype [81]. The gene discussed is CYBB; the disease is colonic neoplasm.