NOX4 and multiple sclerosis: The stimulation of NOX4-derived superoxide production by angiotensin II (Ang II) in neural stem cells significantly increases their proliferation [122], leading to the suggestion that NOX4 level regulates stem cell self-renewal and, therefore, may be an important player in neurodegenerative processes such as Alzhaimer's disease, Parkinson's disease, or multiple sclerosis [122].