NOX4 and hemangioendothelioma: miRNAs can also affect the NOX4-MCP-1 axis critical for hemangioendothelioma; silencing of the enzyme required for miRNA maturation (Dicer) prevented formation of tumors in vivo, accompanied by the upregulation of miR-21a-3p activity targeting the 3′UTR of the NOX4 transcript [96].