Moreover, the deimination site in GFAP observed here, TVEMrDGEVIK, was reported as a possible deimination site in Alzheimer's disease [33, 34] and the core sequence of this peptide, EMrDGEVIK, has also been shown to be reactive with circulating autoantibodies in a patient with relapsing-remittent multiple sclerosis [32]. The gene discussed is GFAP; the disease is early-onset autosomal dominant Alzheimer disease.