Four polymorphisms associated with drug metabolism, CYP2C19 c.681G>A(p.=), CYP2C9 p.Ile359Leu, NAT2 p.Ile114Thr, and NAT2 p.Arg197Gln, were found in patient number 1, and a heterozygous variant KRT8 p.Ile91Val (this gene was previously found as associating with cryptogenic cirrhosis) was found in patient number 2 (Table 3 D). Here, KRT8 is linked to cirrhosis, familial.