Four patients (numbers 1, 2, 3, and 6) possessed a common polymorphism ABCB11 p.Ala444Val (three of them were homozygous for this variant), which in pregnant women or after exposure to hepatotoxic drugs or toxins may associate with intrahepatic cholestasis of pregnancy [31, 32] and other cholestatic syndromes [3, 39, 40]. The gene discussed is ABCB11; the disease is intrahepatic cholestasis.