MTOR and Familial prostate cancer: Compound 37 induced ROS mediated apoptosis in human cervical cancer ME-180 cells (Srinivas et al., 2004), human prostate cancer PC-3 cells and LNCaP cells (Powolny and Singh, 2008), G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin (mTOR) pathway in MCF-7 cells and MDA-MD-231 cells (Kuo et al., 2006).