Amongst them, isoflavonoid 9 revealed the best activity with IC50 values below 10 μM on a panel of cancer cell lines including CCRF-CEM cells (IC50: 3.36 μM), CEM/ADR5000 cells (IC50: 5.51 μM), MDA-MB-231-pcDNA cells (IC50: 5.70 μM), MDA-MB-231-BCRP cells (IC50: 5.87 μM), HCT116 (p53+/+) cells (IC50: 5.68 μM), HCT116 (p53−/−) cells (IC50: 4.60 μM), U87MG cells (IC50: 4.91 μM), U87MG.ΔEGFR cells (IC50: 4.91 μM) and HepG2 cells (IC50: 6.44 μM)(Kuete et al., 2014c). Here, TP53 is linked to cancer.