Hypersensitivity: HCT116 (p53−/−) cells vs. HCT116 (p53+/+) cells (D.R. 0.83); U87MG.ΔEGFR cells vs. U87MG cells (D.R. 0.66); Normal sensitivity: CEM/ADR5000 cells vs. CCRF-CEM cells (D.R. 1.08); induces apoptosis in CCRF-CEM leukemia cells via disruption of the MMP (Kuete et al., 2014a). This evidence concerns the gene TP53 and leukemia.