AKT1 and Alzheimer disease: Indeed, levels of Akt activation (Griffin et al., 2005), mTORC1 phosphorylated at Ser248 only, together with phosphorylated 4EBP1 (Li et al., 2005), p70S6K (Sun et al., 2014) and eIF4E (Li et al., 2005) were significantly increased in AD brain and correlated with Braak staging and tau pathology, indicating that protein translation is radically disordered.