Although the mechanistic details are far less understood than the insulin/IGF pathway, their importance is gaining impetuous as the amino acid profiles or their metabolic enzymes are altered in several disease conditions, including Type 2 diabetes mellitus (T2DM) and AD (Vannini et al., 1982; Wang et al., 2011; Hull et al., 2015). The gene discussed is INS; the disease is Alzheimer disease.