CCL3 and early-onset autosomal dominant Alzheimer disease: Interestingly, CCL3 has been shown to be implicated in the trafficking of key effector cells to the brain during MS [14, 15] and its animal model experimental autoimmune encephalomyelitis [16–18], Alzheimer's disease [19, 20], seizure disorders [21–25], and viral [26, 27] as well as bacterial neuroinflammation [28, 29].