EGFR-TKIs (gefitinib, erlotinib, or afatinib) have been demonstrated to be effective for NSCLC patients with EGFR-activating mutations such as exon19 deletion or exon 21 L858R mutations (Lynch et al., 2004, Paez et al., 2004). Here, EGFR is linked to non-small cell lung carcinoma.