Because CD69 is also expressed by T cells early after TCR and cytokine activation [9], and since CD103 is debated as reliable TRM marker [34], the CD8+CD69+CD103− T cells detected in WML of the MS patients analyzed may denote genuine CD8+ TRM cells, represent activated T cells or a mixture thereof [10, 27, 34, 51]. This evidence concerns the gene CD69 and myeloid sarcoma.