However, in contrast to our findings, downregulation of HDAC1 by RNAi suppressed TGF-β1-induced apoptosis in AML-12 and primary mouse hepatocytes, indicating that HDAC1 functions as a proapoptotic factor in TGF-β1-induced apoptosis [36]. This evidence concerns the gene TGFB1 and acute myeloid leukemia.