HDAC8 and primary cutaneous T-cell non-Hodgkin lymphoma: HDAC8 may be linked to PLCγ1, a signal transducer, absent activation and subsequent failure to release intracellular Ca2+ and reactive oxygen species (ROS) in cutaneous T-cell lymphoma cells, suggesting that HDAC8 may play a role in the induction of apoptosis in T cell lymphomas [19].