We observed that the expression of apoptosis-related factors (BIM, BAX and cleaved CASPASE3) and an invasion-related factor (E-CADHERIN) were higher, while the expression of related invasion factors (TWIST1, SNAIL and MMP9) were lower in glioblastoma cells with HDAC1-shRNA infection. The gene discussed is BCL2L11; the disease is glioblastoma.