Our data first confirmed that HDAC1 mRNA levels were lower in normal brain tissues in comparison with that in glioma tissues, which was supported by glioma patients’ data from TCGA as well as Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, in which the increased HDAC1 protein expression was also found in glioma tissues compared with normal brain tissues. This evidence concerns the gene HDAC1 and glioma.