After 48 h of incubation, both HDAC1-shRNA-U251 (Figure 4A) and HDAC1-shRNA-T98G GBM cells (Figure 4B) showed significantly decreased migratory ability (54 ± 2 cells and 95 ± 11 cells, respectively) compared with the NC cells (123 ± 7 cells and 128 ± 6 cells). This evidence concerns the gene HDAC1 and glioblastoma.