EZH2 and cancer: Through binding to microRNAs (miRNAs) response elements that could directly suppress their target protein expression, UCA1 has an oncogenic function on various human cancers, such as bladder cancer [14], non-small cell lung cancer [15], hepatocellular carcinoma [16] and etc. Hu et al. [17] also reported that UCA1 was physically associated with enhancer of zeste homolog 2 (EZH2), which suppressed p27 (Kip) through histone methylation (H3K27me3) on p27 (Kip) promoter in nucleus.