ADGRF5 and colorectal carcinoma: According to the IHC scoring criteria in the method, 48 of 90 (53.3%) CRC specimens showed high GPR116 expression (GPR116 ++ or GPR116 +++), whereas the remaining 42 CRC samples (46.7%) displayed low GPR116 expression (GPR116- or GPR116 +) (Figure 2A-2B).